“Although scientists are still learning how the SARS-CoV-2 virus is able to invade the brain and central nervous system, the fact that it’s getting in there is clear. Our best understanding is that the virus can cause insult to brain cells, with potential for neurodegeneration to follow on from there,” said Professor Kevin Barnham from the Florey Institute of Neuroscience & Mental Health.

The silent wave

In a review paper published on 22^nd September 2020, researchers put spotlight on the potential long-term neurological consequences of COVID-19, dubbing it the ‘silent wave’. They are calling for urgent action to be taken to have available more accurate diagnostic tools to identify neuro-degeneration early on and a long-term monitoring approach for people who have been infected with the SARS-CoV-2 virus.

The researchers report that neurological symptoms in people infected with the virus have ranged from severe, such as brain hypoxia (lack of oxygen), to more common symptoms such as loss of smell.

“We found that loss of smell or reduced smell was on average reported in three out of four people infected with the SARS-CoV-2 virus. While on the surface this symptom can appear as little cause for concern, it actually tells us a lot about what’s happening on the inside and that is that there’s acute inflammation in the olfactory system responsible for smell,” explained Florey researcher Leah Beauchamp.

Early diagnosis is key

Inflammation is understood to play a major role in the pathogenesis of neurogenerative disease and has been particularly well studied in Parkinson’s. Further research into these illnesses may prove critical for future impacts of SARS-CoV-2.

“We believe that loss of smell presents a new way forward in detecting someone’s risk of developing Parkinson’s disease early. Armed with the knowledge that loss of smell presents in around 90% of people in the early stages of Parkinson’s disease and a decade ahead of motor symptoms, we feel we are on the right track,” added Ms Beauchamp.

Clinical diagnosis of Parkinson’s disease currently relies on presentation of motor dysfunction, but research shows that by this time 50-70% of dopamine cell loss in the brain has already occurred.

“By waiting until this stage of Parkinson’s disease to diagnose and treat, you’ve already missed the window for neuroprotective therapies to have their intended effect. We are talking about an insidious disease affecting 80,000 people in Australia, which is set to double by 2040 before even considering the potential consequences of COVID, and we currently have no available disease-modifying therapies,” said Professor Barnham.

Aiming for cost-effective screening protocol

The researchers hope to establish a simple, cost-effective screening protocol aiming to identify people in the community at risk of developing Parkinson’s, or who are in early stages of the disease, at a time when therapies have the greatest potential to prevent onset of motor dysfunction. They plan to put the proposal forward for funding from the Australian Government’s Medical Research Future Funding scheme.

Additionally, the team have developed two neuroprotective therapies currently under investigation and have identified a cohort of subjects who are ideally suited to study the treatments. Through their research they gained new evidence that people with REM sleep behaviour disorder have a higher predisposition to go on to develop Parkinson’s disease.

“We have to shift community thinking that Parkinson’s not a disease of old age. As we’ve been hearing time and time again, the coronavirus does not discriminate—and neither does Parkinson’s,” said Professor Barnham.

“We can take insight from the neurological consequences that followed the Spanish Flu pandemic in 1918 where the risk of developing Parkinson’s disease increased two to three-fold. Given that the world’s population has been hit again by a viral pandemic, it is very worrying indeed to consider the potential global increase of neurological diseases that could unfold down track.”

He added, “The world was caught off guard the first-time, but it doesn’t need to be again. We now know what needs to be done. Alongside a strategized public health approach, tools for early diagnosis and better treatments are going to be key.”

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Advances in medical sciences means that fewer people die young. As the population grows older, there are newer health problems facing us: age-related neurodegenerative disorders. More and more older people are now finding themselves in the danger zone of Alzheimer’s and Parkinson’s diseases. It is projected that by 2050, the number of people suffering from Alzheimer’s will triple—from five million today to 15 million.

In this TEDx talk given at the John Hopkins University, neuroscientist Dr Mark Mattson establishes a clear link between our energy intake and cognitive abilities of the brain.

In his laboratories, Dr Mattson found that reducing the energy intake in mice could increase their lifespan by 30-40%. So he and his team started studying the effects of energy restrictions on the brain in the context of age-related neurodegenerative diseases. What they found is that when they reduced the energy intake, they could slow down the factors that lead to the degeneration of neurons in the brain.

Dr Mattson shares a few anecdotal insights on the benefits of fasting, a practice that goes back thousands of years before explaining the benefits of intermittent fasting. “Fasting is a challenge to your brain and your brain responds to fasting by activating adaptive stress response pathways that help [it] cope with stress and resist disease,” says Dr Mattson.

Whether you want lose weight, lengthen your lifespan, reduce the risk of neurodegenerative conditions such as Alzheimer’s disease and Parkinson’s disease or simply have greater energy, fasting is a proven way to do it, provided you do it correctly. Watch this talk to find out more.

About Mark Mattson

Chief of the Laboratory of Neurosciences at the National Institute on Aging. He is also a professor of Neuroscience at The Johns Hopkins University. Dr Mattson is one of the foremost researchers in the area of cellular and molecular mechanisms underlying neurodegenerative disorders such as Alzheimer’s Disease, Parkinson’s Disease, and amyotrophic lateral sclerosis.

The post The incredible benefits of intermittent fasting appeared first on Complete Wellbeing.